Anti-CoREST Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-CoREST Rabbit Monoclonal Antibody catalog # M02799-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Histone-lysine N-methyltransferase SETD7;2.1.1.43;Histone H3-K4 methyltransferase SETD7;H3-K4-HMTase SETD7;Lysine N-methyltransferase 7;SET domain-containing protein 7;SET7/9;SETD7;KIAA1717, KMT7, SET7, SET9;

Gene Name

Histone-lysine N-methyltransferase SETD7

UniProt

Q9UKL0

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human CoREST

Clonality

Monoclonal

Clone

Clone: 18R91

Tissue Specificity

Widely expressed. Expressed in pancreatic islets.

Applications

WB,IHC,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. .