Meconine

Meconine is an endogenous metabolite of Noscapine (HY-13716) . Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use[1][2][3].

Product Specifications

CAS Number

[569-31-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/meconine.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OCC2=C1C(OC)=C(OC)C=C2

Molecular Formula

C10H10O4

Molecular Weight

194.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Tsunoda N, Yoshimura H. Metabolic fate of noscapine. II. Isolation and identification of novel metabolites produced by C-C bond cleavage. Xenobiotica. 1979 Mar;9 (3) :181-7. |[2]Yao Y, Xiong Y. Metabolic pathway profiling of the derivative of important herbal component noscapine. Eur J Drug Metab Pharmacokinet. 2016 Feb;41 (1) :27-32. |[3]Dinis-Oliveira RJ. Metabolism and metabolomics of opiates: A long way of forensic implications to unravel. J Forensic Leg Med. 2019 Feb;61:128-140.