Anti-TRIB3 Monoclonal Antibody, Carrier-free

Boster Bio Anti-TRIB3 Monoclonal Antibody catalog # M01414. Tested in WB, IP applications. This antibody reacts with Human.

Product Specifications

Synonyms

RalA-binding protein 1;RalBP1;76 kDa Ral-interacting protein;Dinitrophenyl S-glutathione ATPase;DNP-SG ATPase;Ral-interacting protein 1;RALBP1;RLIP1, RLIP76;

Gene Name

RalA-binding protein 1

UniProt

Q96RU7

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human TRIB3 Disrupts insulin signaling by binding ly to Akt kinases and blocking their activation. May bind ly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity.

Clonality

Monoclonal

Clone

Clone: AEIE-20

Tissue Specificity

Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. .

Applications

WB,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S- (2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. .