Anti-GCN2 EIF2AK4 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-GCN2 EIF2AK4 Rabbit Monoclonal Antibody catalog # M01172. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

Voltage-dependent anion-selective channel protein 1;VDAC-1;hVDAC1;Outer mitochondrial membrane protein porin 1;Plasmalemmal porin;Porin 31HL;Porin 31HM;VDAC1;VDAC;

Gene Name

Voltage-dependent anion-selective channel protein 1

UniProt

Q9P2K8

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human GCN2 Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.

Clonality

Monoclonal

Clone

Clone: ACAA-5

Tissue Specificity

Heart, liver and skeletal muscle.

Applications

WB,IHC,ICC,IF,Flow Cytometry

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. .