Anti-NRCAM Monoclonal Antibody, Carrier-free

Boster Bio Anti-NRCAM Monoclonal Antibody catalog # M03746. Tested in WB, IP applications. This antibody reacts with Human.

Product Specifications

Synonyms

5'-AMP-activated protein kinase subunit beta-1;AMPK subunit beta-1;AMPKb;PRKAB1;AMPK;

Gene Name

5'-AMP-activated protein kinase subunit beta-1

UniProt

Q92823

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human NRCAM Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier.

Clonality

Monoclonal

Clone

Clone: ACOH-14

Tissue Specificity

Expressed in the terminally differentiated epidermis of palms and soles. .

Applications

WB,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by inly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).