Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody catalog # M00211. Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Myelin basic protein;MBP;Myelin A1 protein;Myelin membrane encephalitogenic protein;MBP;

Gene Name

Myelin basic protein

UniProt

P02686

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Myelin Basic Protein

Clonality

Monoclonal

Clone

Clone: IIE-13

Tissue Specificity

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. .

Applications

WB,IHC

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. .