Anti-Myosin Light Chain 2 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Myosin Light Chain 2 Rabbit Monoclonal Antibody catalog # M03215. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform ;MLC-2 ;MLC-2v;Cardiac myosin light chain 2 ;Myosin light chain 2, slow skeletal/ventricular muscle isoform ;MLC-2s/v ;Ventricular myosin light chain 2 ;MYL2 ;MLC2 ;

Gene Name

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

UniProt

P10916

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human Myosin Light Chain 2

Clonality

Monoclonal

Clone

Clone: FHO-13

Tissue Specificity

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. .

Applications

WB,IHC,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). .