Anti-cleaved Caspase-9 CASP9 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-cleaved Caspase-9 CASP9 Rabbit Monoclonal Antibody catalog # M00080-2. Tested in WB, IP applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Caspase-9;CASP-9;3.4.22.62;Apoptotic protease Mch-6;Apoptotic protease-activating factor 3;APAF-3;ICE-like apoptotic protease 6;ICE-LAP6;Caspase-9 subunit p35;Caspase-9 subunit p10;CASP9;MCH6;

Gene Name

Caspase-9

UniProt

P55211

Host

Rabbit

Reactivity

Human,Mouse

Immunogen

A synthesized peptide derived from human cleaved Caspase-9

Clonality

Monoclonal

Clone

Clone: FEE-3

Tissue Specificity

Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. .

Applications

WB,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP- ribose) polymerase (PARP).