Anti-HIF-1 beta ARNT Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-HIF-1 beta ARNT Rabbit Monoclonal Antibody catalog # M02263. Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Aryl hydrocarbon receptor nuclear translocator;ARNT protein;Class E basic helix-loop-helix protein 2;bHLHe2;Dioxin receptor, nuclear translocator;Hypoxia-inducible factor 1-beta;HIF-1-beta;HIF1-beta;ARNT;BHLHE2;

Gene Name

Aryl hydrocarbon receptor nuclear translocator

UniProt

P27540

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human HIF-1 beta

Clonality

Monoclonal

Clone

Clone: EAD-1

Tissue Specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. .

Applications

WB,IHC

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.