Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody catalog # M01585. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Claudin-1;Senescence-associated epithelial membrane protein;CLDN1;CLD1, SEMP1;UNQ481/PRO944;

Gene Name

Claudin-1

UniProt

O95832

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human Claudin 1

Clonality

Monoclonal

Clone

Clone: ABEH-3

Tissue Specificity

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. .

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an in effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22744 MW

Observed Molecular Weight

23 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000

Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

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