Anti-Sumo2/3 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Sumo2/3 Rabbit Monoclonal Antibody catalog # M01282-2. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Small ubiquitin-related modifier 2 ;SUMO-2 ;HSMT3 ;SMT3 homolog 2 ;SUMO-3 ;Sentrin-2 ;Ubiquitin-like protein SMT3B ;Smt3B ;SUMO2 ;SMT3B , SMT3H2;

Gene Name

Small ubiquitin-related modifier 2

UniProt

P61956/P55854

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human Sumo2/3

Clonality

Monoclonal

Clone

Clone: IBG-19

Tissue Specificity

Broadly expressed. .

Applications

WB,IHC,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). .