Anti-NOTCH4 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-NOTCH4 Rabbit Monoclonal Antibody catalog # M02582. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Neurogenic locus notch homolog protein 4;Notch 4;hNotch4;Notch 4 extracellular truncation;Notch 4 intracellular domain;NOTCH4;INT3;

Gene Name

Neurogenic locus notch homolog protein 4

UniProt

Q99466

Host

Rabbit

Reactivity

Human,Mouse

Immunogen

A synthesized peptide derived from human NOTCH4

Clonality

Monoclonal

Clone

Clone: IOC-14

Tissue Specificity

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

Applications

WB,Flow Cytometry

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). .