Anti-SFRP1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-SFRP1 Rabbit Monoclonal Antibody catalog # M01968. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Secreted frizzled-related protein 1;FRP-1;sFRP-1;Secreted apoptosis-related protein 2;SARP-2;SFRP1;FRP, FRP1, SARP2;

Gene Name

Secreted frizzled-related protein 1

UniProt

Q8N474

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human SFRP1

Clonality

Monoclonal

Clone

Clone: ABBA-19

Tissue Specificity

Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. .

Applications

WB,IHC,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. .