Anti-ABCG2/Bcrp Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-ABCG2/Bcrp Rabbit Monoclonal Antibody catalog # M00457. Tested in WB application. This antibody reacts with Human.

Product Specifications

Synonyms

ATP-binding cassette sub-family G member 2;Breast cancer resistance protein;CDw338;Mitoxantrone resistance-associated protein;Placenta-specific ATP-binding cassette transporter;Urate exporter;CD338;ABCG2;ABCP, BCRP, BCRP1, MXR;

Gene Name

ATP-binding cassette sub-family G member 2

UniProt

Q9UNQ0

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human ABCG2

Clonality

Monoclonal

Clone

Clone: AODG-1

Tissue Specificity

Highly expressed in placenta. Low expression in small intestine, liver and colon. .

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. .