Anti-STAT2 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-STAT2 Rabbit Monoclonal Antibody catalog # M01360. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Signal transducer and activator of transcription 2;p113;STAT2;

Gene Name

Signal transducer and activator of transcription 2

UniProt

P52630

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human STAT2

Clonality

Monoclonal

Clone

Clone: HCB-19

Tissue Specificity

Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. .

Applications

WB,IHC,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. .