Anti-TLR7 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-TLR7 Rabbit Monoclonal Antibody catalog # M00376. Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Toll-like receptor 7;TLR7;UNQ248/PRO285;

Gene Name

Toll-like receptor 7

UniProt

Q9NYK1

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human TLR7

Clonality

Monoclonal

Clone

Clone: ABOO-20

Tissue Specificity

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Applications

WB,IHC

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

120922 MW

Observed Molecular Weight

125 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:200

Subcellular Location

Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. .