Anti-Noxa Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Noxa Rabbit Monoclonal Antibody catalog # M02287. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Phorbol-12-myristate-13-acetate-induced protein 1;PMA-induced protein 1;Immediate-early-response protein APR;Protein Noxa;PMAIP1;NOXA;

Gene Name

Phorbol-12-myristate-13-acetate-induced protein 1

UniProt

Q13794

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human Noxa

Clonality

Monoclonal

Clone

Clone: AAFB-16

Tissue Specificity

Highly expressed in adult T-cell leukemia cell line.

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. .