Anti-BMP2 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-BMP2 Rabbit Monoclonal Antibody catalog # M00338. Tested in WB application. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Bone morphogenetic protein 2;BMP-2;Bone morphogenetic protein 2A;BMP-2A;BMP2;BMP2A;

Gene Name

Bone morphogenetic protein 2

UniProt

P12643

Host

Rabbit

Reactivity

Human,Mouse

Immunogen

A synthesized peptide derived from human BMP2

Clonality

Monoclonal

Clone

Clone: AOHD-2

Tissue Specificity

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). .