Anti-IDE/Insulysin Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-IDE/Insulysin Rabbit Monoclonal Antibody catalog # M01358. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Insulin-degrading enzyme;3.4.24.56;Abeta-degrading protease;Insulin protease;Insulinase;Insulysin;IDE;

Gene Name

Insulin-degrading enzyme

UniProt

P14735

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human IDE

Clonality

Monoclonal

Clone

Clone: AOOB-9

Tissue Specificity

Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. .

Applications

WB,IHC

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

117968 MW

Observed Molecular Weight

48 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:100

Subcellular Location

Cytoplasm. Cell membrane. Secreted . Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.