Anti-p21 CDKN1A Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-p21 CDKN1A Rabbit Monoclonal Antibody catalog # M00145-3. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cyclin-dependent kinase inhibitor 1;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;CDKN1A;CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1;

Gene Name

Cyclin-dependent kinase inhibitor 1

UniProt

P38936

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human p21

Clonality

Monoclonal

Clone

Clone: ACG-3

Tissue Specificity

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Applications

WB,IHC,ICC,IF,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. .