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Anti-Phospho-PAK1/2/3 (S144+S141+S139) PAK3 Rabbit Monoclonal Antibody, Carrier-free

Selected Variant

P03124-carrier-free

Size: 100 µL

Boster Bio Anti-Phospho-PAK1/2/3 (S144+S141+S139) PAK3 Rabbit Monoclonal Antibody catalog # P03124. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Phospho Site

S144,S141,S139

Synonyms

Serine/threonine-protein kinase PAK 3;2.7.11.1;Beta-PAK;Oligophrenin-3;p21-activated kinase 3;PAK-3;PAK3;OPHN3;

Gene Name

Serine/threonine-protein kinase PAK 3

UniProt

Q13153/Q13177/O75914

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human Phospho-PAK1/2/3 (S144+S141+S139)

Clonality

Monoclonal

Clone

Clone: CFF-16

Tissue Specificity

Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. .

Applications

WB,IHC,ICC,IF,IP,Flow Cytometry

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

62310 MW

Observed Molecular Weight

40 kDa

Fragment

Rabbit IgG

Applications Notes

WB 1:1000-1:10000<br>IHC 1:50-1:200<br>ICC/IF 1:50-1:200<br>IP 1:50<br>FC 1:50

Subcellular Location

Cytoplasm .

Protein Name

Glutamate receptor 1

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