Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody catalog # P02533. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Phospho Site

Tyr221

Synonyms

Adapter molecule crk;Proto-oncogene c-Crk;p38;CRK;

Gene Name

Adapter molecule crk

UniProt

P46108

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Phospho-CrkII (Tyr221)

Clonality

Monoclonal

Clone

Clone: FDE-3

Tissue Specificity

Expressed in brain, and to a lesser extent in lung, kidney and testis.

Applications

WB,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. .