Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody catalog # P00683. Tested in WB application. This antibody reacts with Human.

Product Specifications

Phospho Site

S724

Synonyms

Serine/threonine-protein kinase/endoribonuclease IRE1;Endoplasmic reticulum-to-nucleus signaling 1;Inositol-requiring protein 1;hIRE1p;Ire1-alpha;IRE1a;Serine/threonine-protein kinase;2.7.11.1;Endoribonuclease;3.1.26.-;ERN1 ;IRE1 ;

Gene Name

Serine/threonine-protein kinase/endoribonuclease IRE1

UniProt

O75460

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Phospho-IRE1 (S724)

Clonality

Monoclonal

Clone

Clone: EGH-5

Tissue Specificity

Ubiquitously expressed. High levels observed in pancreatic tissue. .

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. .