Where can I find the safety data sheet (SDS/MSDS) for Anti-Tau Mapt Antibody (Monoclonal, TAU-2), Carrier-free?

The safety data sheet for Anti-Tau Mapt Antibody (Monoclonal, TAU-2), Carrier-free is available here: https://www.bosterbio.com/msds?sku=MA1093.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Anti-Tau Mapt Antibody (Monoclonal, TAU-2), Carrier-free

Q: What is the catalog number for Anti-Tau Mapt Antibody (Monoclonal, TAU-2), Carrier-free?

The catalog number for Anti-Tau Mapt Antibody (Monoclonal, TAU-2), Carrier-free is MA1093-carrier-free.

Selected Variant

MA1093-carrier-free

Size: 100 µg

Boster Bio Anti-Tau Mapt Antibody (Monoclonal, TAU-2) catalog # MA1093. Tested in IHC, WB applications. This antibody reacts with Bovine, Human.

Product Specifications

Background

The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau are composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau (MTBT1) is mapped to chromosome 17q21.

Synonyms

Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;Mapt;Mtapt, Tau;

Gene Name

Microtubule-associated protein tau

Gene ID

Human(4137), Mouse(17762), Rat(29477)

UniProt

P19332

Host

Mouse

Reactivity

Bovine,Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Bovine microtubule-associated proteins (MAPs).

Clonality

Monoclonal

Clone

Clone: TAU-2

Tissue Specificity

Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited areas of the CNS.

Applications

IHC,WB

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

References & Citations

1. Andreadis, A.; Brown, W. M.; Kosik, K. S. : Structure and novel exons of the human tau gene. Biochemistry 31: 10626-10633, 1992. 2. Donlon, T. A.; Harris, P.; Neve, R. L. : Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract) Cytogenet. Cell Genet. 46: 607, 1987.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

78564 MW

Observed Molecular Weight

272 kDa

Fragment

Mouse IgG1

Specificity

No cross reactivity with other proteins.

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, bovine, By Heat <br>Western blot, 0.5-1μg/ml, Human, bovine<br>

Subcellular Location

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Sequence Similarities

Contains 4 Tau/MAP repeats.

Protein Name