Interleukin-1β Convertase Substrate

IL-1β converting enzyme (ICE, now called caspase-1), a cytosolic enzyme, is responsible for the cleavage of the inactive precursor protein to the active IL-1β. Similarly, caspase-1 hydrolyzes this 14-amino acid peptide that corresponds to the native cleavage site sequence around Asp11?-Ala11?. The peptide is also able to inhibit the cleavage of the precursor to the mature protein.