PBT 1033 (hydrochloride)
PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD) . PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
Product Specifications
CAS Number
648896-70-2
Product Name Alternative
PBT 2 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pbt-1033-hydrochloride.html
Smiles
OC1=C2N=C(C=CC2=C(C=C1Cl)Cl)CN(C)C.[H]Cl
Molecular Formula
C12H13Cl3N2O
Molecular Weight
307.60
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Faux NG, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20 (2) :509-16. |[2]Harbison-Price N, et al. Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2. mSphere. 2020 Mar 18;5 (2) :e00157-20. |[3]Johanssen T, et al. PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning. Neurobiol Dis. 2015 Sep;81:176-85. |[4]Crouch PJ, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem. 2011 Oct;119 (1) :220-30. |[5]Adlard PA, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One. 2011 Mar 11;6 (3) :e17669.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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