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GSK8573

GSK8573 is an inactive control compound for GSK2801 (acetyl-lysine competitive inhibitor of BAZ2A and BAZ2B bromodomains) . GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy. GSK8573 can be used as a structurally related negative control compound in biological experiments[1].

Product Specifications

CAS Number

1693766-04-9

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk8573.html

Concentration

10mM

Purity

99.53

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(C1=CC(C2=CC=CC(OC)=C2)=C3C=C(OCCC)C=CN13)=O

Molecular Formula

C20H21NO3

Molecular Weight

323.39

Precautions

H315, H319

References & Citations

[1]Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59 (4) :1410-24.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD9

Available Sizes

Frequently Asked Questions

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