Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Ataxin 1 Antibody Picoband® (monoclonal, 2B13G8), Carrier-free

Boster Bio Anti-Ataxin 1 Antibody Picoband® (monoclonal, 2B13G8) catalog # M01786-1. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Ataxin-1 is a protein that in humans is encoded by the ATXN1 gene. The ATXN1 gene had been mapped to 6p23 by in situ hybridization. Ataxin-1 (ATXN1), a causative factor for spinocerebellar ataxia type 1 (SCA1), and the related Brother of ATXN1 (BOAT1) are human proteins involved in transcriptional repression. ATXN1 and BOAT1 might participate in several Notch-controlled developmental and pathological processes.

Synonyms

CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains; CD2AP

Gene Name

CD2 associated protein

Gene ID

6310

UniProt

P54253

Host

Mouse

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Ataxin 1, different from the related mouse and rat sequences by one amino acid.

Clonality

Monoclonal

Clone

Clone: 2B13G8

Tissue Specificity

Widely expressed in fetal and adult tissues.

Applications

WB,IHC,Flow Cytometry

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

References & Citations

1. "Entrez Gene: ATXN1 ataxin 1" 2. Tong, X., Gui, H., Jin, F., Heck, B. W., Lin, P., Ma, J., Fondell, J. D., Tsai, C.-C. Ataxin-1 and brother of ataxin-1 are components of the Notch signalling pathway. EMBO Rep. 12: 428-435, 2011. 3. Volz A, Fonatsch C, Ziegler A (Jun 1992). "Regional mapping of the gene for autosomal dominant spinocerebellar ataxia (SCA1) by localizing the closely linked D6S89 locus to 6p24.2----p23.05". Cytogenet Cell Genet 60 (1): 37–9. 4. Volz, A., Boyle, J. M., Cann, H. M., Cottingham, R. W., Orr, H. T., Ziegler, A. Report of the second international workshop on human chromosome 6. Genomics 21: 464, 1994.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01786-1

Product MSDS

https://www.bosterbio.com/msds?sku=M01786-1

Observed Molecular Weight

105 kDa

Fragment

Mouse IgG2b

Applications Notes

Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 μg/1x10<sup>6</sup> cells, Human, Mouse, Rat<br>

Subcellular Location

Cytoplasm, cytoskeleton . Cell projection, ruffle . Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.

Protein Name

activating transcription factor 1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Protein FAM135A (FAM135A) Mouse ELISA Kit
G2888 96 Tests

Protein FAM135A (FAM135A) Mouse ELISA Kit

Ask
View Details
Human Vap-1 (Vascular Adhesion Protein 1) ELISA Kit
FY-EH3764 96 Well

Human Vap-1 (Vascular Adhesion Protein 1) ELISA Kit

Ask
View Details
OATP-F Antibody
E51A11560 100 µL

OATP-F Antibody

Ask
View Details
Tinophyllol
T75510-01 1 mg

Tinophyllol

Ask
View Details
Tinophyllol
T75510-02 5 mg

Tinophyllol

Ask
View Details
Tinophyllol
T75510-03 10 mg

Tinophyllol

Ask
View Details