Lentinan

Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering[1][4].

Product Specifications

CAS Number

37339-90-5

UNSPSC

12352005

Target

Apoptosis; JAK; Keap1-Nrf2

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lentinan.html

Solubility

0.1 M NaOH : 33.33 mg/mL (ultrasonic; adjust pH to 9 with NaOH) |H2O : 50 mg/mL (ultrasonic)

Smiles

[Lentinan]

References & Citations

[1]Meng M, et al. Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway. Int J Biol Macromol. 2022 Dec 1;222 (Pt B) :2375-2391. |[2]Cui H, et al. Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model. Front Cell Infect Microbiol. 2022 May 20;12:892864. |[3]Wang SX, et al. Lentinan ameliorates burn sepsis by attenuating CD4+ CD25+ Tregs. Burns. 2016 Nov;42 (7) :1513-1521. |[4]Chen Q, et al. Upregulation of miR-216a-5p by Lentinan Targeted Inhibition of JAK2/STAT3 Signaling Pathway to Reduce Lung Adenocarcinoma Cell Stemness, Promote Apoptosis, and Slow Down the Lung Adenocarcinoma Mechanisms. Front Oncol. 2021 Nov 25;11:778096. |[5]Ji X, et al. Lentinan improves intestinal inflammation and gut dysbiosis in antibiotics-induced mice. Sci Rep. 2022 Nov 15;12 (1) :19609.|[6]Hu S, et al. Lentinan alleviates diabetic cardiomyopathy by suppressing CAV1/SDHA-regulated mitochondrial dysfunction. Biomed Pharmacother. 2023 Nov;167:115645.