Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CDA Antibody Picoband®, Carrier-free

Boster Bio Anti-CDA Antibody Picoband® catalog # A01578-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene is mapped to 1p36.12. It encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

Synonyms

Cytidine deaminase; Cytidine aminohydrolase; CDA; CDD

Gene Name

cytidine deaminase

Gene ID

978

UniProt

P32320

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CDA, which shares 63% amino acid (aa) sequence identity with both mouse and rat CDA.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Applications

IHC,WB

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

References & Citations

1. Demontis, S., Terao, M., Brivio, M., Zanotta, S., Bruschi, M., Garattini, E. Isolation and characterization of the gene coding for human cytidine deaminase. Biochim. Biophys. Acta 1443: 323-333, 1998. 2. Fitzgerald, S. M., Goyal, R. K., Osborne, W. R. A., Roy, J. D., Wilson, J. W., Ferrell, R. E. Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Hum. Genet. 119: 276-283, 2006. 3. Jahns-Streubel, G., Reuter, C., Auf der Landwehr, U., Unterhalt, M., Schleyer, E., Wormann, B., Buchner, T., Hiddemann, W. Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood 90: 1968-1976, 1997.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01578-1

Product MSDS

https://www.bosterbio.com/msds?sku=A01578-1

Observed Molecular Weight

16 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Western blot, 0.1-0.5μg/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml<br>

Subcellular Location

Cytosol, Extracellular region, Ficolin-1-rich granule lumen, Secretory granule lumen, Tertiary granule lumen.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Anti-SLC8B1/NCLX Polyclonal Antibody
PHP16101 100 μg

Anti-SLC8B1/NCLX Polyclonal Antibody

Ask
View Details
ZNF557 (NM_024341) Human Tagged ORF Clone
RC216440 10 µg

ZNF557 (NM_024341) Human Tagged ORF Clone

Ask
View Details
Recombinant Human CD61/ITGB3 Protein, N-His
E55P0724 50 µg

Recombinant Human CD61/ITGB3 Protein, N-His

Ask
View Details
E2F1 Antibody
27-244 100 µL

E2F1 Antibody

Ask
View Details
Human Prothrombin ELISA Kit
MBS3804529-01 48 Well

Human Prothrombin ELISA Kit

Ask
View Details
Human Prothrombin ELISA Kit
MBS3804529-02 96 Well

Human Prothrombin ELISA Kit

Ask
View Details