Anti-Mouse CD62P DyLight® 488 conjugated Selp Antibody, Carrier-free

Boster Bio Anti-Mouse CD62P DyLight® 488 conjugated Selp Antibody catalog # A01241-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Mouse.

Product Specifications

Background

CD62P is also known as SELP or P-selectin. This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.

Synonyms

P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P; Selp; Grmp

Gene Name

selectin, platelet

Gene ID

20344

UniProt

Q01102

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CD62P recombinant protein (Position: W42-A267).

Clonality

Polyclonal

Label

DyLight®488

Tissue Specificity

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Applications

Flow Cytometry

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Ca (2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Components

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

References & Citations

1. Gremmel T, et al. Impact of diabetes on platelet activation in different manifestations of atherosclerosis. Swiss Med Wkly, 2013 May 28. 2. Kutlar A, et al. Cellular adhesion and the endothelium: P-selectin. Hematol Oncol Clin North Am, 2014 Apr.