Anti-Human SLK DyLight® 488 conjugated Antibody, Carrier-free

Boster Bio Anti-Human SLK DyLight® 488 conjugated Antibody catalog # A01614-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Background

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene. This gene is mapped to chromosome 10q24.33-q25.1. SLK is a kinase with multiple functional domains that is predicted to regulate cytoskeletal organization and responses to apoptotic stimuli.

Synonyms

STE20-like serine/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2; SLK; KIAA0204; STK2

Gene Name

STE20 like kinase

Gene ID

9748

UniProt

Q9H2G2

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human SLK recombinant protein (Position: M1-E232).

Clonality

Polyclonal

Label

DyLight®488

Tissue Specificity

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.

Applications

Flow Cytometry

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Mediates apoptosis and actin stress fiber dissolution. .

Components

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

References & Citations

1. "Entrez Gene: SLK STE20-like kinase (yeast)". 2. Sabourin, L. A., Tamai, K., Seale, P., Wagner, J., Rudnicki, M. A. Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. Molec. Cell. Biol. 20: 684-696, 2000. Note: Erratum: Molec. Cell. Biol. 20: 2949, 2000. 3. Zhapparova, O. N., Fokin, A. I., Vorobyeva, N. E., Bryantseva, S. A., Nadezhdina, E. S. Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome. Molec. Biol. Cell 24: 3205-3214, 2013. [