9-Hydroxyellipticin
9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice[1].
Product Specifications
CAS Number
51131-85-2
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/9-hydroxyellipticin.html
Smiles
OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1
Molecular Formula
C17H14N2O
Molecular Weight
262.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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