β-Amyloid (17-42)

Amyloid 17-42 (Aβ (17-42) ) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP) . Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.