Dasatinib carbaldehyde
Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].
Product Specifications
CAS Number
[2112837-79-1]
Product Name Alternative
BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-abl-binding-moiety-4.html
Purity
99.74
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Molecular Formula
C21H22ClN7O2S
Molecular Weight
471.96
Precautions
H302, H312, H332
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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