Eptapirone

Eptapirone (F11440) is a potent, selective and orally active 5-HT1A receptor agonist (pKi = 8.33) . Eptapirone can inhibit cAMP production. Eptapirone can reduce 5-HT levels and increase corticosterone levels. Eptapirone shows potent anxiolytic and antidepressant potential. Eptapirone can be used for the research of neurological disease, such as anxiety and depression[1].

Product Specifications

CAS Number

[179756-58-2]

Product Name Alternative

F 11440

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/F-11440.html

Purity

99.91

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(N1C)N(CCCCN2CCN(C3=NC=CC=N3)CC2)N=CC1=O

Molecular Formula

C16H23N7O2

Molecular Weight

345.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Koek W, et al. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. J Pharmacol Exp Ther. 1998 Oct;287 (1) :266-83.