NS-1619
Product Specifications
UNSPSC Description
NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. NS-1619 is a highly effective relaxant with an EC50 of about 10?–?30?μM in several smooth muscles of blood vessels and other tissues[1]. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells[2].
Target Antigen
Apoptosis; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis;Membrane Transporter/Ion Channel
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/NS-1619.html
Purity
99.32
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=C1NC2=CC(C(F)(F)F)=CC=C2N1C3=CC(C(F)(F)F)=CC=C3O
Molecular Weight
362.23
References & Citations
[1]H Yamamura, et al. BK channel activation by NS-1619 is partially mediated by intracellular Ca<sup>2+</sup> release in smooth muscle cells of porcine coronary artery. Br J Pharmacol. 2001 Feb;132(4):828-34.|[2]Xiaobing Han,et al. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem Biophys Res Commun. 2008 Oct 17;375(2):205-9.|[3]Xiaoyin Wang, et al. Opening of Ca<sup>2+</sup>-activated K<sup>+</sup> channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice. Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2070-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12496/NS-1619-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12496/NS-1619-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
153587-01-0
Available Sizes
Curated Selection
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