NS-1619
NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. NS-1619 is a highly effective relaxant with an EC50 of about 10-30 μM in several smooth muscles of blood vessels and other tissues[1]. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells[2].
Product Specifications
CAS Number
[153587-01-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/NS-1619.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=C1NC2=CC(C(F)(F)F)=CC=C2N1C3=CC(C(F)(F)F)=CC=C3O
Molecular Formula
C15H8F6N2O2
Molecular Weight
362.23
Precautions
H302, H315, H319, H335
References & Citations
2+2++
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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