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Ethacridine (lactate)

Ethacridine lactate (Acrinol) is a widely used antiseptic and abortifacient. Ethacridine lactate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate is also a poly (ADP-ribose) glycohydrolase (PARG) inhibitor[1][2][3].

Product Specifications

CAS Number

[1837-57-6]

Product Name Alternative

Acrinol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ethacridine_lactate.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)

Smiles

CC(O)C(O)=O.NC1=CC2=NC3=CC=C(OCC)C=C3C(N)=C2C=C1

Molecular Formula

C18H21N3O4

Molecular Weight

343.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Rotin LE, et al. Erlotinib synergizes with the poly (ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101 (11) :e449-e453.|[2]Gupta S, et al. Ethacridine lactate -- a safe and effective drug for termination of pregnancy. Indian J Matern Child Health. 1993;4 (2) :59-61.|[3]Usuki R, et, al. Antibacterial Activity of Acrinol against Organisms Isolated from Clinical Materials and Influence of Light on Antibacterial Activity of Acrinol. Japanese Journal of Pharmaceutical Health Care and Sciences. 2004 Jan; 30 (2) :72-77.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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