YM-90709
YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R) .YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM[1].
Product Specifications
CAS Number
163769-88-8
UNSPSC
12352005
Hazard Statement
H302
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/YM-90709.html
Purity
99.77
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43
Molecular Formula
C22H21N3O2
Molecular Weight
359.42
Precautions
H302
References & Citations
[1]Morokata T, et al. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol. 2002 Nov;2 (12) :1693-702.|[2]Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98 (1) :161-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-5
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![hCG beta (CGB3) Mouse Monoclonal Antibody [Clone ID: HCGb/459]](https://cdn.genprice.uk/products/937/68dd189e061270361e8fd875/imageurl/am50279pu-s.webp)
AM50279PU-S 100 µg
hCG beta (CGB3) Mouse Monoclonal Antibody [Clone ID: HCGb/459]
Sign In for Pricing
View Details 
BNC742298-100 1x 100 µL
Cytokeratin 8/18 (rKRT8.18/1346), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details