Anti-GLUT12/SLC2A12 Antibody Picoband®, APC Conjugate

Boster Bio Anti-GLUT12/SLC2A12 Antibody catalog # PA2167. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Solute carrier family 2, facilitated glucose transporter member 12, also known as SLC2A12, is a protein that in humans is encoded by the SLC2A12 gene. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. By genomic sequence analysis, this gene is mapped to chromosome 6q23.2. SLC2A12 was detected in a perinuclear location in MCF7 cells in the absence of insulin; however, SLC2A12 redistributed to the plasma membrane of MCF7 cells grown continuously in the presence of insulin. This gene acts as facilitative glucose transporter.

Synonyms

Solute carrier family 2, facilitated glucose transporter member 12;Glucose transporter type 12;GLUT-12;SLC2A12;GLUT12, GLUT8;

Gene Name

Solute carrier family 2, facilitated glucose transporter member 12

UniProt

Q8TD20

Host

Rabbit

Reactivity

Rat,Mouse,Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human GLUT12, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. .

Applications

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Facilitative glucose transporter. .

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References & Citations

1. Linden, K. C., DeHaan, C. L., Zhang, Y., Glowacka, S., Cox, A. J., Kelly, D. J., Rogers, S.Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. Am. J. Physiol. Renal Physiol. 290: F205-F213, 2006. 2. Wood, I. S., Hunter, L., Trayhurn, P. Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Biochem. Biophys. Res. Commun. 308: 43-49, 2003.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

66966 MW

Observed Molecular Weight

55 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse<br>

Subcellular Location

Endomembrane system ; Multi- pass membrane protein . Cytoplasm, perinuclear region . Localizes primarily perinuclear region in the absence of insulin.