Anti-Annexin VII/ANXA7 Antibody Picoband®, APC Conjugate

ANXA7 (Annexin A7), also known as ANX7 or SNX, is a protein that in humans is encoded by the ANXA7 gene. Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. Shirvan et al. (1994) isolated genomic clones of the ANXA7 gene and assigned the gene to 10q21.1-q21.2 by study of somatic cell hybrids and by in situ hybridization. Srivastava et al. (2001) concluded that the ANX7 gene exhibits many biologic and genetic properties expected of a tumor suppressor gene and may play a role in prostate cancer progression. Caohuy et al. (1996) present experimental evidence, based on studies of recombinant human ANXA7 and isolated bovine chromaffin cells, that ANXA7 is a Ca (2+)-dependent GTP binding protein. ANXA7 was active in a chromaffin granule aggregation assays in the presence of Ca (2+) and GTP, and was deactivated upon GTP hydrolysis.

A synthetic peptide corresponding to a sequence at the C-terminus of human Annexin VII, different from the related mouse and rat sequences by one amino acid.

1. Caohuy, H., Srivastava, M., Pollard, H. B. Membrane fusion protein synexin (annexin VII) as a Ca(2+)/GTP sensor in exocytotic secretion. Proc. Nat. Acad. Sci. 93: 10797-10802, 1996. 2. Shirvan, A., Srivastava, M., Wang, M. G., Cultraro, C., Magendzo, K., McBride, O. W., Pollard, H. B., Burns, A. L. Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. Biochemistry 33: 6888-6901, 1994. 3. Srivastava, M., Bubendorf, L., Srikantan, V., Fossom, L., Nolan, L., Glasman, M., Leighton, X., Fehrle, W., Pittaluga, S., Raffeld, M., Koivisto, P., Willi, N., Gasser, T. C., Kononen, J., Sauter, G., Kallioniemi, O. P., Srivastava, S., Pollard, H. B. ANX7, a candidate tumor suppressor gene for prostate cancer. Proc. Nat. Acad. Sci. 98: 4575-4580, 2001.

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Western blot, 0.1-0.5μg/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat<br> Immunocytochemistry/Immunofluorescence, 5μg/ml, Human<br> Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human<br>