Anti-Matrilin 3/MATN3 Antibody Picoband®, APC Conjugate

Boster Bio Anti-Matrilin 3/MATN3 Antibody catalog # PA1927. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

MATN3 (Matrilin-3) is a protein that in humans is encoded by the MATN3 gene. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is though to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. By fluorescence in situ hybridization, Belluoccio et al. (1998) mapped the human MATN3 gene to chromosome 2p24-p23. Wagener et al. (2000) mapped the mouse Matn3 gene to the proximal end of chromosome 12, linked to the genes Synd1, Apob, Dtnb, and Kif3c. The human homologs of all 5 of these genes map to 2p23, indicating considerable homology of synteny. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia.

Synonyms

Matrilin-3;MATN3;

Gene Name

Matrilin-3

UniProt

O15232

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Matrilin 3.

Clonality

Polyclonal

Tissue Specificity

Expressed only in cartilaginous tissues, such as vertebrae, ribs and shoulders.

Applications

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References & Citations

1. Belluoccio, D., Schenker, T., Baici, A., Trueb, B. Characterization of human matrilin-3 (MATN3). Genomics 53: 391-394, 1998. 2. Maeda, K., Nakashima, E., Horikoshi, T., Mabuchi, A., Ikegawa, S. Mutation in the von Willebrand factor-A domain is not a prerequisite for the MATN3 mutation in multiple epiphyseal dysplasia. (Letter) Am. J. Med. Genet. 136A: 285-286, 2005. 3. Wagener, R., Kobbe, B., Aszodi, A., Liu, Z., Beier, D. R., Paulsson, M. Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron. Mammalian Genome 11: 85-90, 2000.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.