Anti-MAGI2 Antibody Picoband®, APC Conjugate

Boster Bio Anti-MAGI2 Antibody Picoband® catalog # A04546-2. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene. The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.

Gene Name

MAGI2

Gene ID

9863

UniProt

Q86UL8

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

E.coli-derived human MAGI2 recombinant protein (Position: Q40-P1140). Human MAGI2 shares 97.5% and 96.8% amino acid (aa) sequence identity with mouse and rat MAGI2, respectively.

Clonality

Polyclonal

Applications

WB,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Balbas, M. D., Burgess, M. R., Murali, R., Wongvipat, J., Skaggs, B. J., Mundel, P., Weins, A., Sawyers, C. L. MAFI-2 scaffold protein is critical for kidney barrier function. Proc. Nat. Acad. Sci. 111: 14876-14881, 2014. 2. Bauss, K., Knapp, B., Jores, P., Roepman, R., Kremer, H., v. Wijk, E., Marker, T., Wolfrum, U. Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis. Hum. Molec. Genet. 23: 3923-3942, 2014. 3. Bierzynska, A., Soderquest, K., Dean, P., Colby, E., Rollason, R., Jones, C., Inward, C. D., McCarthy, H. J., Simpson, M. A., Lord, G. M., Williams, M., Welsh, G. I., Koziell, A. B., Saleem, M. A., NephrosS, the UK study of Nephrotic Syndrome. MAGI2 mutations cause congenital nephrotic syndrome. J. Am. Soc. Nephrol. 28: 1614-1621, 2017.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.