Icotrokinra
Icotrokinra is a potent, orally active, and selective IL-23 receptor antagonist that blocks IL-23 signaling, evidenced by inhibiting STAT3 phosphorylation (IC50 = 5.6 pM) in PBMCs and reducing IFN-γ production in NK cells. Its anti-inflammatory efficacy, demonstrated in a rat TNBS-colitis model, supports research into psoriasis, psoriatic arthritis, and inflammatory bowel disease.
Product Specifications
Product Name Alternative
JNJ2113, JNJ-2113, JNJ77242113, JNJ-77242113, PN235, PN-235
Field of Research
Immunology & Inflammation
Purity
98.93% (May vary between batches)
Solubility
H2O:≥ 80 mg/mL; DMSO:80 mg/mL (42.15 mM)
Molecular Weight
1898.17
Storage Conditions
-20°C
Notes
For research use only.
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