Anti-GATB Antibody Picoband®, APC Conjugate

GATB allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).

1. Friederich, M. W., Timal, S., Powell, C. A., Dallabona, C., Kurolap, A., Palacios-Zambrano, S., Bratkovic, D., Derks, T. G. J., Bick, D., Bouman, K., Chatfield, K. C., Damouny-Naoum, N., and 41 others. Pathogenic variants in glutamyl-tRNA(Gln) amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nature Commun. 9: 4065, 2018. Note: Electronic Article. 2. Gross, M. B. Personal Communication. Baltimore, Md. 11/30/2016. 3. Nagao, A., Suzuki, T., Katoh, T., Sakaguchi, Y., Suzuki, T. Biogenesis of glutaminyl-mt tRNA(Gln) in human mitochondria. Proc. Nat. Acad. Sci. 106: 16209-16214, 2009.

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.