Anti-Serine racemase/SRR Antibody Picoband®, APC Conjugate

Boster Bio Anti-Serine racemase/SRR Antibody Picoband® catalog # A02660-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

SRR(serine racemase) is a 37 kDa protein and belongs to the serine/threonine dehydratase family. It plays a role in neuronal activity and a potential biological role in the regulation of N-methyl-D-aspartate (NMDA) receptor activity in these peripheral organs as well. SRR catalyzes the racemization between l- and d-serine.

Synonyms

Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; DPT

Gene Name

dermatopontin

Gene ID

63826

UniProt

Q9GZT4

Host

Rabbit

Reactivity

Human,Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Serine racemase/SRR recombinant protein (Position: A3-E283).

Clonality

Polyclonal

Tissue Specificity

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.

Applications

WB,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. De Miranda, J., Santoro, A., Engelender, S., Wolosker, H. Human serine racemase: molecular cloning, genomic organization and functional analysis. Gene 256: 183-188, 2000. 2. Henneberger, C., Papouin, T., Oliet, S. H. R., Rusakov, D. A. Long-term potentiation depends on release of D-serine from astrocytes. Nature 463: 232-236, 2010. 3. Labrie, V., Fukumura, R., Rastogi, A., Fick, L. J., Wang, W., Boutros, P. C., Kennedy, J. L., Semeralul, M. O., Lee, F. H., Baker, G. B., Belsham, D. D., Barger, S. W., Gondo, Y., Wong, A. H. C., Roder, J. C. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum. Molec. Genet. 18: 3227-3243, 2009.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.