Anti-WDR33 Antibody Picoband®, APC Conjugate

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Chan, S. L., Huppertz, I., Yao, C., Weng, L., Moresco, J. J., Yates, J. R., III, Ule, J., Manley, J. L., Shi, Y. CPSF30 and Wdr33 ly bind to AAUUAAA in mammalian mRNA 3-prime processing. Genes Dev. 28: 2370-2380, 2014. 2. Gross, M. B. Personal Communication. Baltimore, Md. 8/9/2018. 3. Ito, S., Sakai, A., Nomura, T., Miki, Y., Ouchida, M., Sasaki, J., Shimizu, K. A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner. Biochem. Biophys. Res. Commun. 280: 656-663, 2001.

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.