Anti-THEMIS Antibody Picoband®, APC Conjugate

Boster Bio Anti-THEMIS Antibody Picoband® catalog # A07854-3. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Synonyms

Fascin-2; Retinal fascin; FSCN2

Gene Name

fascin actin-bundling protein 2, retinal

Gene ID

387357

UniProt

Q8N1K5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human THEMIS recombinant protein (Position: Q74-H588).

Clonality

Polyclonal

Tissue Specificity

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Applications

WB,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J. A. H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., Gascoigne, N. R. J. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature 504: 441-445, 2013. 2. Fu, G., Vallee, S., Rybakin, V., McGuire, M. V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P. R., Hoerter, J. A. H., Munshi, A., Huang, Y. H., Hu, J., Fox, H. S., Sauer, K., Acuto, O., Gascoigne, N. R. J. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nature Immun. 10: 848-856, 2009. 3. Johnson, A. L., Aravind, L., Shulzhenko, N., Morgun, A., Choi, S.-Y., Crockford, T. L., Lambe, T., Domaschenz, H., Kucharska, E. M., Zheng, L., Vinuesa, C. G., Lenardo, M. J., Goodnow, C. C., Cornall, R. J., Schwartz, R. H. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nature Immun. 10: 831-839, 2009. Note: Erratum: Nature Immun. 11: 97 only, 2010.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.