Anti-HIC5/TGFB1I1 Antibody Picoband®, APC Conjugate

Boster Bio Anti-HIC5/TGFB1I1 Antibody Picoband® catalog # A04630-2. Tested in ELISA, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene. This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; Neuronal K-Cl cotransporter; SLC12A5; KCC2; KIAA1176

Gene Name

solute carrier family 12 member 5

Gene ID

7041

UniProt

O43294

Host

Rabbit

Reactivity

Human,Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human HIC5/TGFB1I1 recombinant protein (Position: E268-A447).

Clonality

Polyclonal

Tissue Specificity

Brain specific. Detected in neuronal cells.

Applications

WB,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Drori, S., Girnun, G. D., Tou, L., Szwaya, J. D., Mueller, E., Kia Xia, Shivdasani, R. A., Spiegelman, B. M. Hic-5 regulates an epithelial program mediated by PPAR-gamma. Genes Dev. 19: 362-375, 2005. Note: Erratum: Genes Dev. 19: 875 only, 2005. 2. Fujimoto, N., Yeh, S., Kang, H.-Y., Inui, S., Chang, H.-C., Mizokami, A., Chang, C. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. J. Biol. Chem. 274: 8316-8321, 1999. 3. Mashimo, J., Shibanuma, M., Satoh, H., Chida, K., Nose, K. Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein. Gene 249: 99-103, 2000.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.